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KMID : 1123920130270020239
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Korean Journal of Oriental Physiology and Pathology
2013 Volume.27 No. 2 p.239 ~ p.245
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Effects of Shiitake Mushroom on Anti-platelet Aggregation and Anti-thrombotic
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Kim Gye-Yeop
Jeong Hyun-Woo
Jeong Dong-Jo
Song Hyung-Bong
Lee Hong-Gyun
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Abstract
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In in vitro study, the anti-platelet aggregation effect of Shiitake mushroom extract was examined by measuring the collagen induced platelet aggregation and the DPPH radical scavenging. In in vitro study, anti-thrombotic effect of Shiitake mushroom extract was examined using the carotid artery thrombosis rat model. Carotid artery thrombosis rat model was made by 35% treatment. After that, we investigate thrombus weight and blood flow. In platelet aggregation test, the extract significantly inhibited platelet aggregation in a concentration dependent manner(p<.001). Also, extract increased DPPH radical scavenging activity in a concentration dependent manner. Extract significantly inhibited thrombus weight to compare with control group. And blood passage time were shorter in the Shiitake mushroom extract supplemented groups than in control group. These results provide experimental evidence that Shiitake mushroom can be used to prevent platelet aggregation and thrombosis, then could apply the clinical diseases such as cardiovascular disease, and so on.
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KEYWORD
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Shiitake mushroom, Anti-platelet aggregation, Anti-thrombotic
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